Description_x000D_ Specificity_x000D_ The antibody does not react with the corresponding phosphorylated form of JunD or JunB._x000D_ Immunogen_x000D_ synthetic phosphoserine63 peptide corresponding to residues around Ser63 of human c-Jun, conjugated to KLH._x000D_ Application_x000D_ Anti-phospho-c-Jun (pSer63) antibody produced in rabbit has been used in microarray analysis to identify the changes in the level of cellular proteins in cells inoculated with Equine influenza virus._x000D_ Physical form_x000D_ Solution in 10 mM HEPES sodium, pH 7.5, containing 150 mM sodium chloride, 100 μg/mL bovine serum albumin, and 50% glycerol._x000D_ Biochem/physiol Actions_x000D_ The protooncogene c-Jun encodes a member of the jun family that forms a component of the transcription factor AP-1 (Activator Protein-1). It dimerizes with a member of the Fos family via the leucine-zipper motif to form AP-1, a factor involved in binding to TPA (12-O-tetradecanoylphorbol 13-acetate) response element (TRE) of various genes that include human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. The dimers formed are involved in the activation of AP-1 dependent genes. AP-1 regulates the transcription of mammalian DDI (DNA-damage-inducible) genes.