Description_x000D_ General description_x000D_ Episialin/mucin (MUC1) is a membrane-tethered, high molecular mass glycoprotein. This molecule has a large mucin-like extracellular domain. This gene is expressed at the apical side of glandular epithelial cells. MUC1 is located on human chromosome 1q22._x000D_ Immunogen_x000D_ The antiserum was produced against synthesized peptide derived from human CD227/MUC1 around the phosphorylation site of Tyr1229._x000D_ Immunogen Range: 1201-1250_x000D_ Physical form_x000D_ Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Episialin/mucin (MUC1) promotes tamoxifen resistance in estrogen receptor-positive breast cancer. Mutation in MUC1 result in upper gastrointestinal cancers. It plays a vital role in protection and lubrication. MUC1 is considered as an antiadhesive protein and may prevent cell to cell interactions by damaging cell-cell and cell-matrix connections._x000D_ Features and Benefits_x000D_ Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.