Description_x000D_ General description_x000D_ Focal Adhesion Kinase (FAK) is a 125 kDa non-receptor protein tyrosine kinase that acts as a substrate for Src and is a key element of_x000D_ integrin signaling. FAK plays an important role in cell spreading, differentiation, migration, cell death, and acceleration of the G1 to S phase_x000D_ transition of the cell cycle. Tyrosine 397 is the autophosphorylation site of FAK, and involved in its initial activation. This phosphorylated site_x000D_ binds Src family SH2 domains and the p85 subunit of PI3-Kinase, and activates cell migration and invasion._x000D_ Specificity_x000D_ Also reacts with FAK-Related Non-Kinase (FRNK)._x000D_ Immunogen_x000D_ The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human FAK that contains serine 732. The sequence is conserved in mouse, rat and chicken._x000D_ Physical form_x000D_ Solution in Dulbecco′s phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, containing 50% glycerol, 1.0 mg/ml BSA (IgG and protease free) and 0.05% sodium azide._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.