Description_x000D_ General description_x000D_ Nuclear receptor subfamily 4 group A member 1 (NR4A1) also known as nuclear hormone receptor 77 (NUR77), belongs to NR4A subfamily nuclear hormone receptors. In human chromosome, the gene NR4A1 is localized on 12q13.13._x000D_ Specificity_x000D_ The antibody detects endogenous levels of Nuclear Receptor NR4A1 only when phosphorylated at serine 351_x000D_ Immunogen_x000D_ Peptide sequence around phosphorylation site of Serine351(L-P-S(p)-K-P) derived from Human Nuclear Receptor NR4A1._x000D_ Physical form_x000D_ Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Nuclear receptor subfamily 4 group A member 1 (NR4A1) is essential for regulation of cell proliferation, apoptosis and energy metabolism. Nur77 is an acetylated protein, modulated by histone acetyltransferase p300 (p300) and histone deacetylase 1 (HDAC1) for its rapid turnover. Nur77 regulates liver kinase B1 (LKB1)- AMP (adenosine monophosphate)-activated protein kinase (AMPK) and plays a major role in glucose metabolism. Expression of Nur77 in skeletal muscle promotes glucose uptake by enhancing insulin pathway and upregulates glycolysis pathway. Expression of Nur77 in hepatocytes promotes gluconeogenesis. Mutation in Nur77 may result in diet-induced obesity and insulin resistance in tissues. Nur77 is a potential drug target for metabolic disorders. NR4A1 is an anti-oncogenic protein that reduces the tumour cell proliferation and metastasis. NR4A1 increases the gastric cancer cells sensitivity towards tumour necrosis factor α (TNF-α) mediated apoptotic pathway. NR4A1 is downregulated in breast cancer, leukemia. NR4A1 plays a crucial role and a potent therapeutic target for fibrosis of endometriosis._x000D_ Features and Benefits_x000D_ Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.