Description_x000D_ General description_x000D_ p16INK4A (cyclin-dependent kinase inhibitor 2A isoform) and p14ARF (cyclin-dependent kinase inhibitor 2A) are encoded by the CDKN2A (cyclin-dependent kinase inhibitor 2A, multiple tumor suppressor) gene. p16INK4A is a low molecular weight protein. This gene is mapped to human chromosome 9p21._x000D_ Immunogen_x000D_ The antiserum was produced against synthesized peptide derived from human p16-INK4a around the phosphorylation site of Ser152._x000D_ Immunogen Range: 107-156_x000D_ Physical form_x000D_ Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ p16INK4A (cyclin-dependent kinase inhibitor 2A isoform) serves as a tumor suppressor and it negatively modulates cell growth by arresting cells in the G1 phase. Mutations in the CDKN2A (cyclin-dependent kinase inhibitor 2A, multiple tumor suppressor) gene is the main reason of inherited susceptibility to melanoma._x000D_ Features and Benefits_x000D_ Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.