Description_x000D_ Immunogen_x000D_ The antiserum was produced against synthesized peptide derived from human Rho/Rac Guanine Nucleotide Exchange Factor 2 around the phosphorylation site of Ser885._x000D_ Immunogen Range: 851-900_x000D_ Physical form_x000D_ Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol._x000D_ Biochem/physiol Actions_x000D_ Rho/Rac guanine nucleotide exchange factor 2 (ARHGEF2) is a microtubule-binding protein, which affects the dynamics of the actin cytoskeleton by inhibiting Rac1 and promoting RhoA activity. ARHGEF2 controls RhoA-dependent cell signaling pathways and play crucial roles in various biological processes. ARHGEF2 signaling influenced by heparanase is involved in the regulation of cytoskeletal dynamics of brain metastatic breast cancer cells (BMBC). Regulation of ARHGEF2 is based on its localization to the microtubules (MT). Depolymerization of MT induce ARHGEF2 activity, whereas relocalization of ARHGEF2 from MT inhibits its activity. ARHGEF2 associates with exocyst complex and plays a vital role in regulating vesicle trafficking. Overexpression of ARHGEF2 enhances metastasis of hepatocellular carcinoma (HCC) via activation of RhoA signaling._x000D_ Features and Benefits_x000D_ Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.