Description_x000D_ General description_x000D_ Specific protein 1 (Sp1) is a transcription regulator that has a transactivation domain at the N-terminus and a DNA-binding domain at the C-terminus, that contains three zinc fingers (ZF). It belongs to the transcription factor family (3) and is located on human chromosome 12q13._x000D_ Immunogen_x000D_ The antiserum was produced against synthesized peptide derived from human SP1 around the phosphorylation site of Thr739._x000D_ Immunogen Range: 706-755_x000D_ Application_x000D_ Anti-phospho-SP1 (pThr739) antibody has been used in western blotting and immunohistochemical staining._x000D_ Physical form_x000D_ Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Specific protein 1 (Sp1) controls the up- and down-regulation of hCtr1 (human high-affinity copper transporter 1). This gene controls the expression of several genes that participates in differentiation, cell cycle and oncogenesis. SP1 has the ability to bind GC/GT‐rich promoter elements with the help of C(2)H(2)‐type zinc fingers at the C‐terminal domains._x000D_ Features and Benefits_x000D_ Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.