Description_x000D_ General description_x000D_ The ZYX (zyxin) gene is mapped to human chromosome 7q34. It encodes a zinc-binding phosphoprotein, belonging to the focal adhesion complex. It is also localized to actin cytoskeleton._x000D_ Immunogen_x000D_ The antiserum was produced against synthesized peptide derived from human Zyxin around the phosphorylation site of Ser142._x000D_ Immunogen Range: 108-157_x000D_ Physical form_x000D_ Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol._x000D_ Biochem/physiol Actions_x000D_ ZYX (zyxin) controls actin filament assembly, and cell motility. It also participates in the regulation of cell division (mitosis), and cell differentiation processes. ZYX is associated with tumor cell proliferation and migration. It is also known to induce the pathogenesis of colon cancer, and hepatocellular carcinoma. Mechanoresponses with respect to integrin and cadherin-based cell adhesion, shows the involvement of zyxin._x000D_ Features and Benefits_x000D_ Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.