Description_x000D_ General description_x000D_ Pleiotrophin (PTN) is a heparin-binding growth factor, also known as heparin-binding growth-associated molecule, heparin affin regulatory peptide, heparin-binding growth factor-8, heparin-binding neurotrophic factor and osteoblast-specific factor. PTN expression is found during development in cells that are in early differentiation stage. The biological functions of PTN include cell migration, proliferation, angiogenesis and differentiation of neural progenitor cells growth of neuritis and fetal lung development. Cellular signalling of PTN is mediated by the receptor protein tyrosine phosphatase (RPTP) β/zeta and is important in tumor growth, angiogenesis and metastasis. Over expression of PTN is observed in neurodegenerative disorders, breast, prostate, lung cancers, glioblastoma, meningioma and melanoma_x000D_ Anti-Pleiotrophin specifically recognizes human pleiotrophin._x000D_ Immunogen_x000D_ purified recombinant human pleiotrophin expressed in Sf 21 cells._x000D_ Application_x000D_ Anti-Pleiotrophin antibody may be used for immunoblotting at a working concentration of 0.1-0.2 μg/ml. The antibody was used for ELISA at a working antibody dilution of 1:200 using cutaneous nerve protein extracts of female Lewis rats._x000D_ Physical form_x000D_ Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.