Description_x000D_ General description_x000D_ Plasmalemma vesicle associated protein (PLVAP) is a rod-like type II membrane amino-glycosylated glycoprotein with molecular mass of 60kDa. It consists of a short intracellular tail and a long extracellular domain. There are four glycosylation sites, a proline-rich region and two large coiled-coil domains. In culture and in situ state it exists as homodimers._x000D_ The PLVAP gene is mapped to human chromosome 19p13.11._x000D_ Immunogen_x000D_ Plasmalemma vesicle-associated protein recombinant protein epitope signature tag (PrEST)_x000D_ Application_x000D_ Anti-PLVAP antibody produced in rabbit has been used in immunohistochemistry._x000D_ Physical form_x000D_ Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide_x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Legal Information_x000D_ Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC_x000D_ Biochem/physiol Actions_x000D_ PLVAP (plasmalemma vesicle associated protein) is an endothelial-specific integral membrane glycoprotein involved in the biogenesis and regulation of stomatal diaphragms of caveolae, transendothelial channels (TECs), vesiculovacuolar organelles (VVOs) and diaphragms of endothelial fenestrae. It is an endothelium-specific protein. It forms the viatl radial fibrils, a key structural component, for the stomatal diaphragm (SD) and fenestral diaphragm (FD). Studies have suggested that PLVAP dimers form fibrils of the diaphragms with microvascular permeability._x000D_ Features and Benefits_x000D_ Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section._x000D_ Every Prestige Antibody is tested in the following ways:_x000D_ • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues._x000D_ • Protein array of 364 human recombinant protein fragments._x000D_ • Validated for multiple commonly used applications such as IHC (Immunohistochemistry), IF (Immunofluorescence), and WB (Western Blot)_x000D_ Linkage_x000D_ Corresponding Antigen APREST85160.