Description_x000D_ General description_x000D_ POT1 (Protection of Telomere 1, also known as POTE1 and POT1-like telomere end-binding protein) is a highly conserved single-strand telomeric binding protein. POT1 is one of the six core telomere-binding proteins termed the telosome2 or shelterin. POT1 has eukaryotic homologs and first identified in S. pombe. Mice that carry two POT1 genes encoding two proteins (POT1a and POT1b). Human genome contains one gene that encodes four alternative splice variants (v2, v3, v4, and v5)._x000D_ Application_x000D_ Anti-POT1 antibody produced in rabbit has been used in immunoblotting._x000D_ Target description_x000D_ POT1 (Protection of Telomere 1, also known as POTE1and POT1-like telomere end-binding protein) is a highly conserved single-strand telomeric binding protein and is required for both chromosomal end protection and telomere length regulation._x000D_ Physical form_x000D_ Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Protection of Telomere 1 (POT1) binds single-stranded telomeric DNA through two NH2-terminal oligonucleotide-binding folds and interacts with TTP1 through the COOH-terminal region. It is required for both chromosomal end protection and telomere length regulation. Genetic disruption of the two POT1 genes in mice revealed two different phenotypes. Knockout of Pot1a alone results in embryonic lethality. Pot1a/b double knockout cells showed enhanced telomere dysfunction induced foci.