Description_x000D_ General description_x000D_ The progesterone receptor (PgR) is an estrogen-regulated protein. It has been proposed that expression of PgR determination indicates a responsive estrogen receptor (ER) pathway. A number of studies have shown that PgR determination provides supplementary information to ER._x000D_ Progesterone receptor (PGR) belongs to the steroid/thyroid hormone receptor family of ligand-activated transcription factors. It possesses the amino-terminal AF1 region, the central DNA-binding domain (DBD) and the carboxyl-terminal ligand- binding domain (LBD). The PGR gene is localized on human chromosome 11q22.1._x000D_ Immunogen_x000D_ Recombinant protein encoding aa 412-526 of human progesterone receptor._x000D_ Physical form_x000D_ 0.1 ml rabbit monoclonal antibody supplied as tissue culture supernatant in TBS/1% BSA buffer pH 7.5 with less than 0.1% sodium azide._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Progesterone receptor (PGR) functions as a transcription factor,_x000D_ which modulates the transcription of target genes in response to progesterone and other hormones. It is phosphorylated on multiple sites and at times, the phosphorylation changes according to the hormone involved. During hormone unavailability, PGR is bound to heat shock proteins. When the ligand binds, it causes the release of PGR from heat shock proteins. It is then translocated to the nucleus, where it binds to its DNA response elements (SREs) and to the components of the transcription machinery. PGR also binds to chromatin templates and results in chromatin remodeling adjacent to the PGR-binding sites._x000D_ Features and Benefits_x000D_ Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.