Description_x000D_ General description_x000D_ P2X receptors are membrane-bound ion channels that are activated by extracellular ATP. These receptors consist of seven known isoforms ranging from P2X1 to P2X7 . P2X7 modulates several cellular functions such as cell death, cytokine release and mRNA synthesis . Anti-Purinergic Receptor P2(X7) (extracellular) antibody is specific for P2X7 in rats and mice. The antibody also reacts with human K562 (Chronic myelogeneous leukemia); WEHI-231 (Lymphoma, B lymphocyte) and HL-60 (promyelocytic leukemia) cell lines._x000D_ Immunogen_x000D_ Synthetic peptide corresponding to residues 136-152 of mouse P2X7 receptor. This antigenic epitope is identical in humans and rats; whereas in bovines, only 14/17 residues are identical._x000D_ Application_x000D_ Anti-Purinergic Receptor P2(X7) (extracellular) antibody is suitable for use in immunoblot and western blot (1:200, using rat brain lysate and human cell lines)._x000D_ Physical form_x000D_ Lyophilized from phosphate buffered saline, pH 7.4, 1% BSA, and 0.05% sodium azide._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.