Description_x000D_ General description_x000D_ Rab11 (Ras-related protein) has three subtypes -Rab11a, Rab11b, and Rab25. Rab11a (Ras-related protein Rab-11A) belongs to the ras-like small GTP-binding protein superfamily. It is found in nonpolarized cells like fibroblasts and erythroleukemia cells. It is located on human chromosome 15q21.3-q22.31 and on mouse chromosome 9. Rab11a is expressed abundantly._x000D_ Immunogen_x000D_ synthetic peptide corresponding to amino acid residues 1-17 from human Rab11. This sequence is completely conserved in human, mouse, and rat and 94% conserved in C. elegans and amphibians._x000D_ Application_x000D_ Anti-Rab11 has been used in western blotting and immunohistochemistry._x000D_ Physical form_x000D_ Solution in phosphate buffered saline containing 1 mg/mL bovine serum albumin and 0.05% sodium azide._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Rab11a (Ras-related protein Rab-11A) participates in the modulation of basolateral to apical transcytosis. It controls TRPV5/6 (Ca2+-selective members) channel trafficking. It is essential for the production of bile canalicular in WIF-B9 cells (rat hepatoma/human fibroblast hybrid cells).