Description_x000D_ General description_x000D_ Rab (Ras-related in brain) 13 is encoded by the gene mapped to human chromosome 1q21.3. It is a member of Rab family of proteins. The encoded protein is ubiquitously expressed and is mainly localized at the trans-Golgi network, on recycling endosomes, on late endosomes, and at the plasma membrane._x000D_ Application_x000D_ Anti-Rab13 (C-terminal) antibody produced in rabbit has been used in:_x000D_ • immunoprecipitation_x000D_ • immunofluorescence_x000D_ • western blotting_x000D_ Physical form_x000D_ Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Rab (Ras-related in brain) 13 plays a vital role in both biosynthetic and endosomal recycling pathways. It is also involved in the regulation of membrane trafficking at the level of endosomes. Rab13 helps in the transport of cargo (integrins) to the plasma membrane, disruption of cell-cell adhesions. Additionally, it aids in cell migration by rearranging actin cytoskeleton attached to surface delivery of selective proteins. It also plays a crucial role in cancer progression. Rab13 is also involved in a putative secretory function in osteoclasts.