Description_x000D_ General description_x000D_ Receptor for advanced glycation end products (RAGE), also known as advanced glycosylation end-product specific receptor (AGER) is encoded by the gene mapped to human chromosome 6p21. The encoded protein is a member of the immunoglobulin superfamily of cell surface molecules._x000D_ Immunogen_x000D_ synthetic peptide corresponding to amino acid residues 362-380 from rat RAGE. This sequence is 100% conserved in mouse and 70% conserved in human._x000D_ Application_x000D_ Anti-RAGE (Receptor for Advanced Glycation Endproducts) antibody produced in rabbit has been used in western blot and flow cytometry._x000D_ Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below._x000D_ Western Blotting (1 paper)_x000D_ Physical form_x000D_ Solution in phosphate buffered saline containing 1.0 mg/mL bovine serum albumin and 0.05% sodium azide._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ The soluble form of receptor for advanced glycation end products (RAGE) has a function in the Wnt pathway. RAGE has a role in the development of inflammatory and cellular damage, as well as cellular toxicity. It has been associated with diabetic atherosclerosis. AGER/RAGE also modulates cell proliferation, differentiation and apoptosis.{93