Description_x000D_ General description_x000D_ SIRT5 (Sirtuin 5) is a mitochondrial matrix protein belonging to the class III of the sirtuin family. It is localized inside the mitochondria and within the cytosol and nucleus. The protein is widely expressed in the brain, heart, liver and kidney. It is composed of very short amino and carboxyl terminal sequences flanking region with the conserved, catalytic sirtuin center domain._x000D_ Immunogen_x000D_ SIRT5 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human SIRT5._x000D_ Application_x000D_ Anti-SIRT5 antibody produced in chicken is suitable for western blot and indirect ELISA._x000D_ Physical form_x000D_ Supplied in PBS with 0.02% sodium azide._x000D_ Biochem/physiol Actions_x000D_ SIRT5 (Sirtuin 5) is associated with metabolism and aging process. It has been reported in a study that SIRT5 influences urea cycle pathway by NAD-dependent deacetylation and subsequent activation of carbamoyl phosphate synthetase 1 (CPS1), which plays a vital role in the initial step of urea cycle for the detoxification and removal of ammonia. In non-small cell-lung cancer cells. SIRT5 contributions have also been observed for the cancer cell growth and drug resistance. Study shows that SIRT5 may possess oncogenic property._x000D_ Features and Benefits_x000D_ Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more._x000D_ Linkage_x000D_ The action of this antibody can be blocked using blocking peptide SBP3500496.