Description_x000D_ General description_x000D_ Sp1 (Simian virus 40 protein-1) is a ubiquitous sequence specific nuclear transcription factor that recognizes GGGGCGGGGC and related sequences (GC boxes) on numerous viral and cellular genes. The sequence specificity of DNA binding is conferred by three c-terminal Cys2His2-type zinc -fingers and its affinity is regulated by a different region. Sp1 is an abundant phosphorylated and O-glycosylated protein that is expressed in most cells in levels dependent on cell type and developmental stage. It is a member of a family comprising Sp1, Sp2, Sp3, Sp4 and at least twelve additional Sp1 like members._x000D_ Immunogen_x000D_ synthetic peptide of human Sp1, amino acids 436-454 with N-terminally added lysine, conjugated to KLH._x000D_ Application_x000D_ Anti-Sp1 antibody produced in rabbit has been used in western blotting and immunoprecipitation._x000D_ Physical form_x000D_ Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide_x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Sp1 (Simian virus 40 protein-1) has been implicated in maintenance of homeostasis and in cellular responsiveness to environmental changes. It mainly appears to be an activation transcription factor.