Description_x000D_ General description_x000D_ The SDC-4 (syndecan-4) gene encodes a membrane-spanning proteoglycan which can bear heparan sulfate and chondroitin sulfate chains. Syndecan-4 is predominantly expressed on smooth muscle cells, epithelial cells and cardiomyocytes. The SDC-4 gene is mapped to human chromosome 20q13.12. Anti-Syndecan4 antibody detects endogenous levels of total syndecan-4 protein._x000D_ Immunogen_x000D_ The antiserum was produced against synthesized peptide derived from human Syndecan4._x000D_ Immunogen Range: 145-194_x000D_ Physical form_x000D_ Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Syndecan-4 (SDC-4) is associated with bone development and osteogenesis by regulating fibroblast growth factor-2 (FGF2). SDC-4 gene expression promotes cell division, migration and adhesion. It is essential for wound healing and takes part in inflammation and fibrosis. An abnormal SDC-4 expression is observed in response to stress and metastatic tumor. Growth factors such as FGF2, TNF-α (tumor necrosis factor α) and TGF-β (transforming growth factor β) also tend to alter SDC-4 expression. It is implicated as a biomarker in cardiovascular disease._x000D_ Features and Benefits_x000D_ Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.