Description_x000D_ General description_x000D_ Transcription factor 12 (TCF12) is a class I member of helix-loop-helix (HLH) protein family, encodes for class II basic helix-loop-helix protein (bHLHb) transcription factor. In human chromosome, the gene TCF12 is localized on 15q21.3._x000D_ Immunogen_x000D_ TCF12 antibody was raised against a 19 amino acid peptide near the amino terminus of human TCF12._x000D_ Application_x000D_ Anti-TCF12 antibody produced in rabbit has been used in immunoblotting._x000D_ Physical form_x000D_ Supplied in PBS with 0.02% sodium azide._x000D_ Biochem/physiol Actions_x000D_ Transcription factor 12 (TCF12) represses E-cadherin expression and thereby controls metastasis of colorectal cancer cells. TCF12 might play a role in controlling the proliferation of neural stem cells and progenitor cells. TCF12-TWIST1 (twist family bHLH transcription factor 1) heterodimers is required for the development of normal coronal suture. Mutations in the TCF12 heterodimer causes coronal craniosynostosis. TCF12 is critically required for regulating human mesodermal and hematopoietic specification in the early development. Mutations in TCF12 affects the transcriptional activity and leads to anaplastic oligodendroglioma, a rare brain tumor._x000D_ Features and Benefits_x000D_ Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more._x000D_ Linkage_x000D_ The action of this antibody can be blocked using blocking peptide SBP3500566.