Description_x000D_ General description_x000D_ Tet methyl cytosine dioxygenase 2 (TET2), a TET oncogene family member 2/ten-eleven translocation 2, is a tumour suppressor gene which encodes a DNA demethylase enzyme. In human chromosome, the gene TET2 is localized on 4q24._x000D_ Physical form_x000D_ Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Tet methyl cytosine dioxygenase 2 (TET2) catalyses the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in DNA. TET2 is essential for normal myelopoiesis, epigenetic programming, embryonic stem cell maintenance and early development. Mutations in TET2 leads to myelodysplastic syndromes (MDS), myeloproliferative disorder, myeloproliferative neoplasms (MPN). Mutations also causes different leukaemia like chronic myelomonocytic leukaemia (CMML), acute myeloid leukaemias (AML), secondary AML (sAML) and myeloid malignancies. TET2 regulates mast cell differentiation and proliferation and cytokine production.