Description_x000D_ General description_x000D_ Anti-TF2E2 Antibody detects endogenous levels of total TF2E2 protein._x000D_ The gene GTF2E2 (general transcription factor IIE subunit 2) is mapped to human chromosome 8p12. The protein has a serine-rich region, a centrally located forkhead domain, a leucine repeat motif, a region similar to the bacterial σ factor subdomain 3, a bHLH (basic region-helix-loop-helix) motif and a bHL (basic region-helix-loop) sequence._x000D_ Immunogen_x000D_ The antiserum was produced against synthesized peptide derived from human TF2E2._x000D_ Immunogen Range: 151-200_x000D_ Physical form_x000D_ Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol._x000D_ Biochem/physiol Actions_x000D_ The gene GTF2E2 (general transcription factor IIE subunit 2) encodes the β subunit of transcription factor IIE (TFIIEβ). It has DNA binding ability and is essential for transcription. GTF2E2 also binds to RNA polymerase II. In patients with trichothiodystrophy, mutation in GTF2E2 is responsible for destabilization of TFIIE._x000D_ Features and Benefits_x000D_ Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.