Description_x000D_ General description_x000D_ Transmembrane protein 106A (TMEM106A) is a type II transmembrane protein localized in mitochondria and plasma membrane. In human chromosome, the gene TMEM106A is localized at 17q21.31._x000D_ Immunogen_x000D_ Antibody was raised against a 14 amino acid peptide near the amino terminus of human TMEM106A._x000D_ Physical form_x000D_ Supplied at 1 mg/mL in PBS with 0.02% sodium azide._x000D_ Biochem/physiol Actions_x000D_ In gastric cancer cells, transmembrane protein 106A (TMEM106A) is methylated and downregulated. Expression of TMEM106A leads to suppression of cell growth and leads to apoptosis of gastric cancer cells. Expression of TMEM106A in renal cancer suppresses cell growth, cell migration and induces caspase 3 dependent apoptosis. TMEM106A is expressed in all neural cell lines. The mRNA levels of TMEM106A is upregulated in Alzheimer′s disease (AD) brain when compared to non-AD brain._x000D_ Features and Benefits_x000D_ Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more._x000D_ Linkage_x000D_ The action of this antibody can be blocked using blocking peptide SBP3500658.