Description_x000D_ General description_x000D_ YB-1 (Y-box-binding protein 1) is a member of the evolutionary conserved Cold-Sock Domain (CSD) proteins. It is ubiquitously expressed in adult tissues and throughout embryogenesis._x000D_ Immunogen_x000D_ synthetic peptide corresponding to amino acidds 137-150 of human YB-1, conjugated to KLH. The corresponding sequence is identical in rat and mouse proteins._x000D_ Application_x000D_ Anti-YB-1 (N-terminal) antibody has been used in immunoblotting and immunofluorescence._x000D_ Physical form_x000D_ Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ YB-1 (Y-box-binding protein 1) plays a major role in a wide variety of cellular functions such as transcriptional and translation regulation, DNA repair, drug resistance and stress responses. YB-1 deficient embryos die during late embryonic development and exhibit a runting phenotype.