Description_x000D_ General description_x000D_ Artesunate is a semisynthetic derivative of artemisinin used to treat malaria. It has also been shown to effective against other parasites such as liver flukes. Artesunate also demonstrates cytotoxic action against cancer cell lines of different tumor types._x000D_ Packaging_x000D_ 100, 500 mg in poly bottle_x000D_ Biochem/physiol Actions_x000D_ Artesunate acts on the electron transport chain, generates local reactive oxygen species, and causes the depolarization of the mitochondrial membrane. It inhibits TNFα-induced production of proinflammatory cytokines via inhibition of NF-κB and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes._x000D_ Other Notes_x000D_ Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.