Description_x000D_ General description_x000D_ Asparaginase is a bacterial enzyme and also a chemotherapeutic drug._x000D_ Application_x000D_ Asparaginase from Escherichia coli has been used:_x000D_ • to compare the cytotoxic effect of L-asparaginase purified from Streptomyces brollosae NEAE-115_x000D_ • as a standard in asparaginase assay to quantify asparaginase activities in various eel tissues_x000D_ • to elicit amino acid deprivation_x000D_ Packaging_x000D_ 100, 1000 units in serum bottle_x000D_ Biochem/physiol Actions_x000D_ Asparaginase (ASNase) products are usually obtained from Escherichia coli and Erwinia chrysanthemi. These enzymes can block the synthesis of protein in tumor cells. It shows high activity in the G1 phase of the cell cycle. It is capable of causing pancreatitis in leukemia patients._x000D_ Asparaginase is used in enzymatic assays and to convert asparagine to aspartic acid. Asparaginase is used to reduce the formation of acrylamide in starchy food products. It is also used as a chemotherapy agent for acute lymphoblastic leukemia . Product A3809 is from Escherichia coli and is provided as a lyophilized powder containing sodium chloride._x000D_ Asparaginase may cause cell death in leukemic cells by converting the necessary L-asparagine to aspartic acid and ammonia . Asparaginase is allosterically regulated and is crucial for proper cell functioning ._x000D_ Unit Definition_x000D_ One unit will liberate 1.0 μmole of ammonia from L-asparagine per min at pH 8.6 at 37 °C._x000D_ Physical form_x000D_ Lyophilized powder containing sodium chloride_x000D_ Preparation Note_x000D_ Chromatographically purified_x000D_ Analysis Note_x000D_ Protein determined by biuret.