Description; Amino Acid Sequence; Arg-Leu-Cys-Arg-Ile-Val-Val-Ile-Arg-Val-Cys-Arg-OH (Disulfide bridge: 3-11); General description; Chemical structure: peptide; Application; Bactenecin′s activity has been studied as a cyclic molecule as well as in a linear form.[2] It was used to study the functional role of Trk1p in the mechanism of other antifungal peptides.[3] It has been used to study chemokine and cytokine production, alteration of gene expression in host cells, and inhibition of proinflammatory responses of host cells to bacterial components.[1]; Biochem/physiol Actions; Bactenecin is a 12-amino acid cationic antimicrobial peptide from bovine neutrophils. It strongly binds to LPS and perturbs the structure, fluidity and permeability of the inner membrane. This results in the leakage of cytosol and subsequent death of the bacteria.[4]; Other Notes; Peptide antibiotic, originally isolated from bovine neutrophil granules; Keep container tightly closed in a dry and well-ventilated place.