Description_x000D_ General description_x000D_ Chemical structure: peptide_x000D_ β-defensin-3 (BD-3) is an anti-microbial peptide produced by airway epithelial cells, lung-derived epithelial cells and keratinocytes. It has a molecular weight of 5kDa. The gene encoding this protein is localized on human chromosome 8p23.1. Recombinant human β-defensin-3 (BD-3) is an antimicrobial peptide, which belongs to the distinct family of β-defenisns. Recombinant human BD-3 is a 5.1 kDa protein containing 45 amino acid residues._x000D_ Biochem/physiol Actions_x000D_ β-defensin-3 (BD-3) associates with bacterial products which reduce the effect of inflammatory cytokine responses. The protein has been shown to stimulate the production of interferon-α and activate monocytes through toll-like receptors 1 and 2. It antagonizes the activation of C-X-C motif chemokine receptor 4 (CXCR4)._x000D_ Physical form_x000D_ Sterile filtered and lyophilized with no additives._x000D_ Reconstitution_x000D_ Centrifuge the vial prior to opening. Avoid freeze-thaw cycles._x000D_ Reconstitute in 10 mM Acetic acid to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.