Description General description Produced and qualified by HWI pharma services GmbH. Exact content by quantitative NMR can be found on the certificate. Application Fluorescent stain for heparin in mast cells Biochem/physiol Actions An alkaloid with weak antibiotic properties. Substrate for MDR efflux pumps. Antimicrobial activities of berberine is potentiated by the MDR inhibitor 5´-methoxyhydnocarpin (5´-MHC). Berberine upregulates the expression of Pgp in hepatoma cells. Treatment with berberine potentially results in the reduced accumulation of chemotherapeutic drugs.