Description General description Mobilizes Ca2+ specifically from Ins(1,4,5)P3-sensitive Ca2+ stores by inhibiting microsomal and sarcoplasmic reticulum Ca2+-ATPase activity. Does not affect mitochondrial Ca2+ fluxes or plasma membrane Ca2+/Mg2+ ATPase activity. Inhibits prostaglandin E2 and prostacyclin formation in osteoblast-like cell lines. Mobilizes Ca2+ specifically from the Ins(1,4,5)P3-sensitive Ca2+ stores by inhibiting microsomal and sarcoplasmic reticulum Ca2+-ATPase activity. Does not affect mitochondrial Ca2+ fluxes or plasma membrane Ca2+/Mg2+ ATPase activity. Useful for the study of endomembrane Ca2+ stores and plasma membrane Ca2+ permeability pathways. Packaging 100 mg in Plastic ampoule Biochem/physiol Actions Cell permeable: no Primary Target micosomal and sarcoplasmic reticulation Ca2+ ATPase activity Product does not compete with ATP. Reversible: no Warning Toxicity: Standard Handling (A) Other Notes Salvador, J.M., and Mata, A.M. 1998. Arch. Biochem. Biophys. 351, 272. Leis, H.J., et al. 1996. Br. J. Pharmacol. 117, 540. Khan, Y.M., et al. 1995. Biochemistry 34, 14385. Hassessian, H., et al. 1994. Br. J. Pharmacol. 112, 1118. Khodorova, A.B., and Astashkin, E.I. 1994. FEBS Lett. 353, 167. Schilling, W.P., et al. 1992. Biochem. J.284, 521. Wictome, M., et al. 1992. FEBS Lett.304, 109. Mason, M.J., et al. 1991. J. Biol. Chem.266, 20856. Kass, G.N., et al. 1989. J. Biol. Chem.264, 15192.; Description