Description_x000D_ General description_x000D_ BMPs (bone morphogenetic proteins) belong to the transforming growth factor-β (TGF-β) superfamily of structurally related signaling proteins. BMP-12 is highly conserved across species. The gene encoding this protein is localized on human chromosome 2. Recombinant human BMP-12 is a 27kDa disulfide-linked homodimer containing two 122 amino acid polypeptide chains._x000D_ Application_x000D_ Bone morphogenetic protein (BMP-12)/GDF-7 (growth differentiation factor 7) has been used as a supplement in human adipose stem cells (hASCs) growth media._x000D_ Biochem/physiol Actions_x000D_ As implied by their name, BMPs (bone morphogenetic proteins) promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. BMP-12 regulates chondrogenesis, bone morphogenesis, and neuron differentiation. It also has a role in seminal vesicle development._x000D_ Physical form_x000D_ Sterile filtered and Lyophilized without additives._x000D_ Reconstitution_x000D_ Centrifuge the vial prior to opening. Avoid freeze-thaw cycles._x000D_ Reconstitute to a concentration of 0.1-1.0 mg/mL in water containing BSA (50 mg BSA per 1 mg of protein). This solution can then be diluted into other aqueous buffers.