Description_x000D_ Biochem/physiol Actions_x000D_ Cellular responses to BMP-2 are mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. BMPs stimulate angiogenesis by inducing the production of VEGF-A by osteoblasts. Human, mouse, and rat BMP-2 demonstrate 100% homology._x000D_ Physical form_x000D_ Lyophilized from a 0.2 μm filtered buffered solution._x000D_ Analysis Note_x000D_ The biological activity is measured by its ability to induce alkaline phosphatase production by ATDC5 chondrogenic cells.