Description; Application; Bryostatin 1 has been used to study its effects on spontaneous Crohn′s disease (CD) like colitis in mice.[3] It has also been used to study its effects as an anthelmintic drug on adult Syphacia muris infection in rats.[4]; Packaging; 10 μg in ampule; Biochem/physiol Actions; Bryostatin 1 (Bry1) is a macrocyclic lactone.[1] This synaptogenic compound[2] is obtained from the marine bryozoan Bugula neritina.[3] Bry1 is capable of reversing synaptic loss. It can enable synaptic maturation in animal models with several neurological disorders.[1] It possesses antidepressant activity, when administered intracebroventricularly.[2] Bry1 is known to participate in protecting cell tight junctions (TJs), anti-inflammatory functions and immune regulation.[3]; Macrolactone isolated from the marine bryozoan Bugula neritina that initially activates and subsequently down-regulates protein kinase C (PKC). More potent than phorbol myristate acetate for translocating PKCδ and ε.; Other Notes; Binds to glass and plastic in aqueous solutions