Description General description A cell-permeable pyrazolopyrimidine-carbox A cell-permeable pyrazolopyrimidine-carboxamide that selectively inhibits c-Myc-Max dimer DNA binding activity (IC50 = 23 µM) by preventing c-Myc-Max heterodimer formation, while affecting Max, Jun, C/EBPα homodimers, or Jun-Fos heterodimer DNA binding only at much higher concentrations (IC50 = ≥54 µM). Shown to selectively inhibit c-Myc-Max-dependent transcription (by 77% against E-Box promoter-driven reporter transcription at 10 µM), cancer proliferation, and anchorage-independent colony formation (Effective conc. 10-20 µM). Packaging 10 mg in Glass bottle Biochem/physiol Actions Cell permeable: yes IC₅₀ = 23 and 54 µM for c-Myc/Max and Max/Max dimerization Primary Target α-helical dimerization motifs of c-Myc/Max factors Reversible: yes Secondary Target α-helical dimerization motifs of Max/Max factors Packaging Packaged under inert gas Warning Toxicity: Standard Handling (A) Reconstitution Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. Other Notes Kiessling, A., et al. 2006. Chem. Biol.13, 745.