Description General description A potent, irreversible inhibitor of Cathepsin B in vivo and in vitro (IC50 = 2.24 nM for rat liver cathepsin B). An epoxysuccinyl peptide that acts as a potent, irreversible, and specific inhibitor of cathepsin B (IC50 = 2.24 nM for rat liver cathepsin B). Reduces ischemia-induced neuronal death. Exhibits lower membrane permeability when compared to CA-074 Me (Cat. No. 205531). Packaging 1 mg in Plastic ampoule Biochem/physiol Actions Cell permeable: no Primary Target cathepsin B Product does not compete with ATP. Reversible: no Target IC50: 2.24 nM for rat liver cathepsin B Warning Toxicity: Standard Handling (A) Reconstitution Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Other Notes Chan, V.J., et al. 1999. Biochem. J. 340, 113. Tsuchiya, K., et al. 1999. Exp. Neurol. 155, 187. Yamamoto, A., et al. 1997. J. Biochem.121, 974. Inubushi, T., et al. 1994. J. Biochem. 116, 282. Murata, M., et al. 1991. FEBS Lett. 280, 307. Towatari, T., et al. 1991. FEBS Lett. 280, 311.