Description General description A ubiquitous Ca2+-binding protein distributed in eukaryotic cells that serves as a major physiological effector for a wide range of cellular responses. The Ca2+-calmodulin complex is involved in the maintenance of intracellular Ca2+ homeostasis, as well as in the regulation of the intracellular concentration of other second messengers, such as cyclic AMP and inositol trisphosphate. Calmodulin highly purified from bovine brain. Note: This product is not to be used for animal treatment, in vivo research or in any other contact procedure with livestock. A ubiquitous Ca2+-binding protein that serves as a physiological effector of a wide range of biological processes. Calmodulin highly purified from bovine brain. Note: this product cannot be used for animal treatment, in vivo research, or any contact procedure with livestock. Packaging 1, 5 mg in Plastic ampoule Yes Warning Toxicity: Standard Handling (A) Unit Definition One unit is defined as the amount of calmodulin that gives rise to 50% of the maximal enzyme activation of a standard level of activator-deficient calcineurin. Physical form Lyophilized from 30 mM HEPES, 1 mM CaCl₂, 0.1 mM DTT, pH 7.4. Reconstitution Following reconstitution, aliquot and freeze (-20°C or -70°C). Aqueous stock solutions are stable for up to 2 months at -20°C or for up to 4 months at -70°C. Please refer to the vial label for lot-specific reconstitution volume. Other Notes Bagchi, I.C., et al. 1992. J. Biol. Chem.267, 3024. O′Neil, K.T., and DeGrado, W.F. 1990. Trends Pharmacol. Sci. 15, 59. Harrison, J.K., et al. 1988. J. Neurochem.51, 345. Gopalakrishna, R., and Anderson, W.B. 1983. J. Biol. Chem.258, 2405. Gopalakrishna, R., and Anderson, W.B. 1982. Biochem. Biophys. Res. Commun.104, 830. Sharma, B.K., et al. 1979. Adv. Cyclic Nucleotide Res.10, 187.