Description General description A 17-residue peptide based on the calmodulin-binding domain of myosin light chain kinase (MLCK). Binds to calmodulin with high affinity (Kd = 6 pM). Inhibits calmodulin activation of MLCK-catalyzed phosphorylation of smooth muscle regulatory light chain(MLC). A 17-residue peptide based on the calmodulin-binding domain of myosin light chain kinase (MLCK). Binds to calmodulin with high affinity (Kd = 6 pM). Packaging 500 μg in Plastic ampoule Biochem/physiol Actions Cell permeable: no Kd = 6 pM in binding to calmodulin Primary Target Calmodulin Product does not compete with ATP. Reversible: no Warning Toxicity: Standard Handling (A) Sequence Ac-Arg-Arg-Lys-Trp-Gln-Lys-Thr-Gly-His-Ala-Val-Arg-Ala-Ile-Gly-Arg-Leu-NH₂ Physical form Supplied as a trifluoroacetate salt. Reconstitution Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Other Notes Torok,K., et al. 1998. Biochemistry 37, 6188. Török, K., and Trentham, D.R. 1994. Biochemistry33, 12807.