Description General description A potent, cell-permeable and irreversible inhibitor of calpain II (k2 = 28,900 M-1s-1). Also acts as an inhibitor of cathepsin L (k2 = 680,000 M-1s-1). A potent, cell-permeable, and irreversible inhibitor of calpain II (k2 = 28,900 M-1s-1). Also acts as an inhibitor of cathepsin L (k2 = 680,000 M-1s-1). Packaging 1 mg in Plastic ampoule Biochem/physiol Actions Cell permeable: yes Primary Target calpain 2 Product does not compete with ATP. Reversible: no k₂ = 28,900 M⁻¹s⁻¹ in the inhibition of calpain II; k2 = 680,000 M⁻¹s⁻¹ in the inhibition of cathepsin L Warning Toxicity: Standard Handling (A) Sequence Z-Leu-Leu-Tyr-CH₂F Reconstitution Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. Analysis Note single spot by TLC Other Notes Dutt, P., et al. 1998. FEBS Lett. 436, 367. Angliker, H., et al. 1992. J. Med. Chem. 35, 216.