Description General description A specific and reversible inhibitor of CPP32/Apopain/Yama (IC50 = 0.2 nM). A member of the ICE/CED-3 family of cysteine proteases, which are important in apoptosis. A very potent, specific, and reversible inhibitor of caspase-3 (IC50 = 200 pM), caspase-6, caspase-7, caspase-8, and caspase-10. Packaging 1 mg in Glass bottle Yes 5 mg in Plastic ampoule Biochem/physiol Actions Cell permeable: no Primary Target Capase-3, capase-6, capase-7, capase-8, capase-10 Product does not compete with ATP. Reversible: yes Target IC50: 200 pM against caspase-3 Warning Toxicity: Standard Handling (A) Sequence Ac-Asp-Glu-Val-Asp-CHO Reconstitution Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Other Notes Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608. Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312. Nicholson, D.W. 1996. Nature Biotech. 14, 297. Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841. Nicholson, D.W., et al. 1995. Nature376, 37.; Description