Description General description A potent, selective, reversible, and competitive non-peptide inhibitor of cathepsin G (IC50 = 53 nM and Ki = 63 nM). Weakly inhibits chymotrypsin (Ki = 1.5 µM) and does not have any significant inhibitory effect on thrombin, factor Xa, factor IXa, plasmin, trypsin, tryptase, proteinase 3, and human leukocyte elastase (IC50 > 100 µM). A potent, selective, reversible, competitive, non-peptide inhibitor of cathepsin G [IC50 = 53 nM and Ki = 63 nM]. Weakly inhibits chymotrypsin (Ki = 1.5 µM) and poorly inhibits thrombin, factor Xa, factor IXa, plasmin, trypsin, tryptase, proteinase 3, and human leukocyte elastase (IC50 > 100 µM). Packaging 1 mg in Plastic ampoule Packaged under inert gas 5 mg in Glass bottle Biochem/physiol Actions Cell permeable: no Primary Target cathepsin G Product does not compete with ATP. Reversible: yes Target Ki: 63 nM for cathepsin G Warning Toxicity: Standard Handling (A) Reconstitution Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Other Notes Greco, M.N., et al. 2002. J. Am. Chem. Soc.124, 3810.