Description General description Cysteine protease inhibitor. Selectively inhibits cathepsin B (k2/Ki = 1 x 104 M-1 sec-1), cathepsin L (k2/Ki = 1.5 x 105 M-1 sec-1), cathepsin S (k2/Ki = 6.6 x 104 M-1 sec-1), and papain (k2/Ki = 1 x 103 M-1 sec-1). Cysteine protease inhibitor. Selectively inhibits cathepsin B (k2/Ki = 1.0 x 104 M-1sec-1), cathepsin L (k2/Ki = 1.5 x 105 M-1sec-1), cathepsin S (k2/Ki = 6.6 x 104 M-1sec-1), and papain (k2/Ki = 1.0 x 103 M-1sec-1). Half-life in buffered solution (pH 5-9) = 37 h (30°C); 300 h (0°C). Half-life in buffered solution (pH 5-9) = 37 h (30°C); 300 h (0°C). Packaging 1 mg in Plastic ampoule Biochem/physiol Actions Cell permeable: no Primary Target cathepsin B Product does not compete with ATP. Reversible: no k₂/Ki = 1 x 10⁴ M⁻¹ sec⁻¹ Warning Toxicity: Standard Handling (A) Sequence Z-Phe-Gly-NHO-Bz-pOMe Reconstitution Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Other Notes Demuth, H.-U., et al. 1996. Biochim. Biophys. Acta1295, 179. Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671.