Description_x000D_ General description_x000D_ CD40L (cluster of differentiation 40 ligand) belongs to the tumor necrosis factor (TNF) family, and is expressed by basophils, B cells, monocytic cells, natural killer cells, platelets, mast cells and T cells. It is predominantly expressed on pro-inflammatory T cells. It also exists in a soluble form._x000D_ Biochem/physiol Actions_x000D_ CD40L (cluster of differentiation 40 ligand) is active in its membrane-bound form. It interacts with CD40 and functions as a proinflammatory and procoagulant agent. The serum levels of soluble CD40L is elevated in malignant middle cerebral artery infarction (MMCAI) patients, especially in non-surviving patients._x000D_ Physical form_x000D_ Lyophilized from PBS_x000D_ Reconstitution_x000D_ Reconstitute with 100 μL deionized water._x000D_ Other Notes_x000D_ Human CD40L (aa 116-261) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG®-tag._x000D_ Legal Information_x000D_ FLAG is a registered trademark of Sigma-Aldrich Co. LLC