Description_x000D_ General description_x000D_ Chemical structure: ß-lactam_x000D_ Application_x000D_ Cefotaxim has been used to find new residues involved in cefotaxime hydrolysis in CTX-M β-lactamases, to study antibiotic-susceptible and -resistant Streptococcus pneumoniae infections, and to study pneumococcal pneumonia and the pharmokinetics of various treatments. It may be used to study the effects of binding and inhibition of penicillin binding protein 2 (PBP2) on bacterial mucopeptide synthesis._x000D_ Biochem/physiol Actions_x000D_ Cefotaxim inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes._x000D_ Other Notes_x000D_ Broad spectrum third generation cephalosporin antibiotic._x000D_ Keep container tightly closed in a dry and well-ventilated place.