Description_x000D_ General description_x000D_ Chelerythrine chloride (CHE), a benzophenanthridine alkaloid is an inhibitor of protein kinase C (PKC). It is the active component of Macleaya cordata._x000D_ Application_x000D_ Chelerythrine chloride has been used:_x000D_ • as a supplement in heat-inactivated late-embryo extract or late-embryo extract to inhibit protein kinase C (PKC) activity_x000D_ • for in vitro Xenopus experiments_x000D_ • as a PKC inhibitor in HL-1 cells, to block the PKC pathway to study its effects on doxazosin-induced galectin-3 and collagen expression_x000D_ Packaging_x000D_ 1, 5 mg in glass insert_x000D_ Biochem/physiol Actions_x000D_ Chelerythrine chloride (CHE) is capable of preventing the growth and apoptosis in human gastric cancer BGC-823 cells. It possesses several biological effects and also can induce the phosphorylation of a ~20 kDa protein present in the mitochondrial fraction of the rat retina._x000D_ Features and Benefits_x000D_ This compound is featured on the P2 Receptors: P2X Ion Channel Family and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.