Description_x000D_ General description_x000D_ Cholecalciferol (vitamin D3), a fat-soluble steroid is produced in the skin._x000D_ Application_x000D_ Cholecalciferol has been used:_x000D_ • to induce arterial medial calcification (AMC) in mice_x000D_ • to study its impact in vascular remodeling associated with vascular calcification (VC) in murine model of obesity and insulin resistance (ob/ob mice)_x000D_ • to study its effect on anchorage dependent growth of RWPE2-W99 cells in monolayer culture_x000D_ Packaging_x000D_ 1 g in ampule_x000D_ 25 g in glass bottle_x000D_ 250 mg in ampule_x000D_ Biochem/physiol Actions_x000D_ Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis.