Description_x000D_ Packaging_x000D_ 5, 25 mg in glass bottle_x000D_ Biochem/physiol Actions_x000D_ cisTPD is a constitutive androstane receptor (CAR) agonist that inhibits FOXO1 and HNF4 driven expression of the gluconeogeneis PEPCK and glucose-6-phosphatase. cisTPD reduces blood glucose levels, insulin sensitivity and weight gain in rats fed a high fat diet._x000D_ Features and Benefits_x000D_ This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.