Description General description Codeine is an opiate used for its analgesic, antitussive, and sedative properties and is the second-most predominant alkaloid in opium. This reference material is suitable for use as starting material in calibrators and controls for LC/MS and GC/MS testing methods in clinical toxicology, forensic analysis, pharmaceutical research, and pain prescription monitoring. As a widely popular recreational drug, codeine is regulated under various narcotic control laws in countries such as Australia, New Zealand, Romania, Sweden, and the United States.