Description_x000D_ General description_x000D_ Colchicine is a tricyclic alkaloid that can stay in circulation for 20 to 40 hours post intake. Leucocytes harbour maximum colchicine. It contains three hexameric rings termed A, B and C._x000D_ Application_x000D_ Colchicine has been used:_x000D_ • as an inhibitor of tubulin polymerization in bone-marrow-derived macrophages_x000D_ • for the inhibition of in vitro neurite outgrowth in human neuronal cells_x000D_ • as microtubule destabilizer to induce peripheral neuropathy in induced pluripotent stem cell derived neurons (iPSC-Neurons)_x000D_ Packaging_x000D_ 1, 5 g in glass bottle_x000D_ 500 mg in glass bottle_x000D_ Biochem/physiol Actions_x000D_ Colchicine interacts with albumin and binds to tubulin. Its association with tubulin impacts autophagic vacuole fusion with lysosomes. It inhibits tyrosine kinases and phospholipases. Colchicine may be useful for treating acute coronary syndromes. It is prescribed for treating rheumatologic conditions including familial mediterranean fever (FMF) and acute gouty arthritis._x000D_ Colchicine is an inhibitor of microtubule polymerization which blocks chromosome segregation during meiosis. Consequently, Colchicine is used to induce polyploidy (tetraploid) in plant cells._x000D_ Preparation Note_x000D_ Preparation and Use