Description General description Inhibitor of mitosis that is useful in cell division studies. Disrupts microtubules and inhibits tubulin polymerization. Induces apoptosis in PC12 cells and in cerebellar granule cells. Major alkaloid of Colchicum autumnale. Inhibitor of mitosis used in cell division studies. Disrupts microtubules and inhibits tubulin polymerization. Induces apoptosis in pheochromocytoma (PC12) cells and in cerebellar granule cells. Packaging 1 g in Alu drum Biochem/physiol Actions Cell permeable: no Primary Target Inhibitor of mitosis Product does not compete with ATP. Reversible: no Warning Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I) Other Notes Bonfoco, E., et al. 1995. Exp. Cell Res.218, 189. Lindenboim, L., et al. 1995. J. Neurochem.64, 1054. Leung, M.F., and Sartorelli, A.C. 1992. Leuk. Res.16, 929. Santell, L. 1992. Exp. Cell Res. 201, 358. Salmon, E.D., et al. 1984. J. Cell Biol.99, 1066. Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.; Description