Description General description Native, human C3a complement component. Single chain, 77 amino acid peptide. Activation of either complement pathway can result in formation of C3-cleaving enzyme (C3 convertases) on target surfaces. The C3 convertase enzymes of either complement activation pathway will cleave the C3 α-chain at peptide bond 77, resulting in the production and release of the C3a peptide. C3a, one of the three complement-derived anaphylatoxins, expresses a wide variety of biological activities, which include smooth muscle contraction, platelet and neutrophil activation and aggregation, skin wheal and flare, and immunoregulatory reactions. Native, human C3a complement component. Single chain, 77 amino acid peptide. Activation of either complement pathway can result in formation of C3-cleaving enzymes (C3 convertases) on target surfaces. The C3 convertase enzymes of either complement activation pathway will cleave the C3 α-chain at peptide bond 77 resulting in the production and release of the C3a peptide. C3a, one of the three complement-derived anaphylatoxins, expresses a wide variety of biological activities which include smooth muscle contraction, platelet and neutrophil activation and aggregation, skin wheal and flare, and immunoregulatory reactions. Packaging 50 μg in Plastic ampoule Please refer to vial label for lot-specific concentration. Warning Toxicity: Standard Handling (A) Physical form In PBS, pH 7.2, sterile-filtered through a 0.22 µm filter. Preparation Note Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV. Reconstitution Following initial thaw, aliquot and freeze (-70°C). Other Notes Hugli, T.E. 1989. Curr. Top. Micro. Immunol. 153, 181. Hugli, T.E. 1986. Complement 3, 111.